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Ageless
Cover of Ageless
Ageless
The New Science of Getting Older Without Getting Old
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“A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD
Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.
“A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD
Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.
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    The Age of Aging

    Cast your mind back 25,000 years. It’s late on a warm spring afternoon in what we now call southern France, and you’re gathering firewood a short way from your camp. The men are out hunting, carrying spears and seeking out game like deer and bison. You and your fellow nomads look pretty much like modern humans, but life is very different—not least because of the ever-­present risk that it will end suddenly.

    At 28 years old you’re doing quite well for a prehistoric woman. There are risks everywhere. A tiny scratch could get infected and kill you; you could meet a sudden end in an accident or animal attack; or other prehistoric humans, hungry and desperate, could murder you in a fight. Most tragic of all, though, out of the five children you’ve given birth to, two have died—one shortly after birth from what we’d now understand to be a serious fever, and another aged three who you buried just a month ago. Prehistory is a dangerous place to live, and death seems to strike at random, often without obvious cause. There’s no understanding of germs or birth defects—perhaps you blame capricious, vengeful gods or spirits in an attempt to make sense of it all.

    It’s hard for us to work out exactly how long prehistoric humans lived, not least because prehistory is defined as the period prior to written records. There were no birth certificates or insurance companies compiling detailed mortality tables. However, surveys of bones at a handful of archaeological sites, plus extrapolation from modern hunter–gatherer societies, give us some idea—and it’s at once better and worse than you might expect.

    First, the bad news: life expectancy was poor, probably somewhere between 30 and 35 years. Statistically speaking, a lot of you reading this would already be dead. However, life expectancy is a number which can obscure as much as it reveals. This is because it’s an average and comes with all the attendant statistical pitfalls. The main reason that it was so strikingly low in prehistory was the appalling rate of infant and child mortality. Infections in the first few years of life struck down many, many babies and children. You probably had only a 60 percent chance of making it to 15 years old—barely better than tossing a coin. This huge number of deaths at young ages drags down the average age at death significantly.

    However, if your coin came up heads and you made it to your late teens, you could expect to live another 35 or 40 years, taking you comfortably into your fifties. This “remaining life expectancy” is itself an average, so it’s quite likely that a few ancient humans did make it into their sixties or seventies—what we, in modern times, would start to call “old age.” A headline 35-year life expectancy both masks the terrible toll of childhood deaths and underplays how long the oldest early humans lived. Such is the challenge of summarizing a complex phenomenon like human lifespan with a single number.

    This was the story for tens of thousands of years: eye-watering levels of child mortality held overall life expectancy down; most who made it to adulthood lived decent but not exceptionally long lives. For millennia, death was an omnipresent feature of human life, often rapid and without warning. Those who escaped the capricious clutches of infectious disease, injury or bad luck were greeted by an inexplicable state of decline which we’d now recognize as aging: a gradual loss of faculties in a world where fitness, keen senses and mental...
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  • AudioFile Magazine Author and narrator Andrew Steele is a specialist in the "new science of getting older without getting old." No one dies of old age, Dr. Steele argues, and as we reduce the underlying causes of death, we increase average longevity. Putting aside the question of where we'll put all these additional old folks, Steele offers a fascinating survey of contemporary medicine and the research on longevity in animals and humans. Although Steele is a television personality in Britain, as the audiobook's narrator, his delivery strikes the American ear as too rapid, and he runs words together. While his voice may lack charm and accessibility, the topic of longevity is fascinating. D.A.W. © AudioFile 2021, Portland, Maine
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Ageless
Ageless
The New Science of Getting Older Without Getting Old
Andrew Steele
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